Assess The Potential Protective Effect of Germinated Tiger Nuts on Some Biochemical and Histopathological Markers in Hepatotoxicity Rats

المؤلفون

1 Nutrition and Food Science Depart., Faculty of Home Economics, Helwan University, Egypt

2 Home Economics Depart., Faculty of Specific Education–Aswan Univ., Egypt

المستخلص

A current study was undertaken to evaluate the potential hepatoprotective effect of germinated tiger nuts (GTNs) on the betterment of some biochemical and histopathological markers in hepatotoxicity rats. Fifty rats (200±7g) were exploited and haphazardly separated into five groups (n=7). Group 1 was employed as a negative control group (normal rats). Group 2 (positive control group) was injected intraperitoneal (IP) with CCl4 at a dose of 2 ml/kg of b. wt. once/week for 6 weeks and fed on the basal diet lone. The remaining three groups (3, 4 and 5) were IP with 2 ml/kg of b.wt. of CCL4 once/week (6 weeks) and fed on the prepared diet with GTNs at levels of 5, 10 and 15% respectively. In comparison with the normal rats, positive rats have a significant decrease in body weight (BW), relative body weight gain (RBWG%) and feed consumed (FC), as well as activity of CAT, SOD and GPx enzymes in liver tissues. There is a significant increase in serum levels of AST, ALT, ALP, albumin, Cr, UN, UA, total lipids, TG and TC, as well as MDA level in liver tissues. In comparison with the positive group, injecting rats with CCl4 and feeding the complemented diet with the different proportions of GTNs (5, 10 and 15%) had a significant improvement in BWG, RBWG, FC and FER, as well as the tested parameters in serum and liver tissues. Histological investigation of the liver showed a remarkable advancement in being detected by normal hepatocytes and slight hepatic steatosis, especially in treated rats with 10 and 15% of GTNs. Eventually, GTNs might mitigate the failure of liver and kidney functions and improve the lipid profile and antioxidant defense due to its antioxidant ingredients, therefore eliminating the deleterious effect of some toxic agents like CCl4

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